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| Regular Season | Cubs Opponent | Pregame | First Pitch | |
| Tuesday, May 17 | vs. Pirates | 6:05 | 6:40 | |
| Wednesday, May 18 | vs. Pirates | 6:05 | 6:40 | |
| Thursday, May 19 | vs. Diamondbacks | 6:05 | 6:40 | |
| Friday, May 20 | vs. Diamondbacks | 12:45 | 1:20 | |
| Saturday, May 21 | vs. Diamondbacks | 12:45 | 1:20 | |
| Sunday, May 22 | vs. Diamondbacks | 12:45 | 1:20 | |
| Monday, May 23 | at Reds | 5:05 | 5:40 | |
| Tuesday, May 24 | at Reds | 5:05 | 5:40 | |
| Wednesday, May 25 | at Reds | 5:05 | 5:40 | |
| Thursday, May 26 | at Reds | 11:00 | 11:35 | |
| Saturday, May 28 | at White Sox | 5:40 | 6:15 | |
| Sunday, May 29 | at White Sox | 12:35 | 1:10 | |
| Monday, May 30 | vs. Brewers | Game 1 12:05pm | Game 2 6:05pm | |
| Tuesday, May 31 | vs. Brewers | 6:30 | 7:05 | |
| Wednesday, June 1 | vs. Brewers | 6:30 | 7:05 | |
| Thursday, June 2 | vs. Cardinals | 6:30 | 7:05 | |
| Friday, June 3 | vs. Cardinals | 12:45 | 1:20 | |
| Saturday, June 4 | vs. Cardinals (DH Game 1) | 11:45 | 12:20 | |
| Saturday, June 4 | vs. Cardinals (DH Game 2) | 5:40 | 6:15 | |
| Sunday, June 5 | vs. Cardinals | 12:45 | 1:20 | |
| Tuesday, June 7 | at Orioles | 5:30 | 6:05 | |
| Wednesday, June 8 | at Orioles | 5:30 | 6:05 | |
| Friday, June 10 | at Yankees | 5:30 | 6:05 | |
| Saturday, June 11 | at Yankees | 5:40 | 6:15 | |
| Sunday, June 12 | at Yankees | 11:30 | 12:05 | |
| Monday, June 13 | vs. Padres | 6:30 | 7:05 | |
| Tuesday, June 14 | vs. Padres | 6:30 | 7:05 | |
| Wednesday, June 15 | vs. Padres | 6:30 | 7:05 | |
| Thursday, June 16 | vs. Padres | 12:45 | 1:20 | |
| Friday, June 17 | vs. Braves | 12:45 | 1:20 | |
| Saturday, June 18 | vs. Braves | 12:45 | 1:20 | |
| Sunday, June 19 | vs. Braves | 12:45 | 1:20 | |
| Monday, June 20 | at Pirates | 5:30 | 6:05 | |
| Tuesday, June 21 | at Pirates | 5:30 | 6:05 | |
| Wednesday, June 22 | at Pirates | 5:30 | 6:05 | |
| Thursday, June 23 | at Pirates | 11:00 | 11:35 | |
| Friday, June 24 | at Cardinals | 6:40 | 7:15 | |
| Saturday, June 25 | at Cardinals | 12:40 | 1:15 | |
| Sunday, June 26 | at Cardinals | 12:40 | 1:15 | |
| Tuesday, June 28 | vs. Reds | 6:30 | 7:05 | |
| Wednesday, June 29 | vs. Reds | 6:30 | 7:05 | |
| Thursday, June 30 | vs. Reds | 6:30 | 7:05 | |
| Friday, July 1 | vs. Red Sox | 12:45 | 1:20 | |
| Saturday, July 2 | vs. Red Sox | 5:40 | 6:15 | |
| Sunday, July 3 | vs. Red Sox | 12:45 | 1:20 | |
| Monday, July 4 | at Brewers | 2:35 | 3:10 | |
| Tuesday, July 5 | at Brewers | 6:35 | 7:10 | |
| Wednesday, July 6 | at Brewers | 12:35 | 1:10 | |
| Thursday, July 7 | at Dodgers | 8:35 | 9:10 | |
| Friday, July 8 | at Dodgers | 8:35 | 9:10 | |
| Saturday, July 9 | at Dodgers | 8:35 | 9:10 | |
| Sunday, July 10 | at Dodgers | 2:35 | 3:10 | |
| Tuesday, July 12 | vs. Orioles | 6:30 | 7:05 | |
| Wednesday, July 13 | vs. Orioles | 6:30 | 7:05 | |
| Thursday, July 14 | vs. Mets | 6:30 | 7:05 | |
| Friday, July 15 | vs. Mets | 12:45 | 1:20 | |
| Saturday, July 16 | vs. Mets | 12:45 | 1:20 | |
| Sunday, July 17 | vs. Mets | 12:45 | 1:20 | |
| Friday, July 22 | at Phillies | 5:30 | 6:05 | |
| Saturday, July 23 | at Phillies | 4:30 | 5:05 | |
| Sunday, July 24 | at Phillies | 10:30 | 11:05 | |
| Monday, July 25 | vs. Pirates | 6:30 | 7:05 | |
| Tuesday, July 26 | vs. Pirates | 12:45 | 1:20 | |
| Thursday, July 28 | at Giants | 8:10 | 8:45 | |
| Friday, July 29 | at Giants | 8:40 | 9:15 | |
| Saturday, July 30 | at Giants | 7:30 | 8:05 | |
| Sunday, July 31 | at Giants | 2:30 | 3:05 | |
| Tuesday, August 2 | at Cardinals | 6:10 | 6:45 | |
| Wednesday, August 3 | at Cardinals | 6:10 | 6:45 | |
| Thursday, August 4 | at Cardinals | 6:10 | 6:45 | |
| Friday, August 5 | vs. Marlins | 12:45 | 1:20 | |
| Saturday, August 6 | vs. Marlins | 12:45 | 1:20 | |
| Sunday, August 7 | vs. Marlins | 12:45 | 1:20 | |
| Monday, August 8 | vs. Nationals | 6:30 | 7:05 | |
| Tuesday, August 9 | vs. Nationals | 6:30 | 7:05 | |
| Wednesday, August 10 | vs. Nationals | 12:45 | 1:20 | |
| Thursday, August 11 | at Reds (Field of Dreams) | TBD | ||
| Saturday, August 13 | at Reds | 5:05 | 5:40 | |
| Sunday, August 14 | at Reds | 11:35 | 12:10 | |
| Monday, August 15 | at Nationals | 5:30 | 6:05 | |
| Tuesday, August 16 | at Nationals | 5:30 | 6:05 | |
| Wednesday, August 17 | at Nationals | 11:30 | 12:05 | |
| Friday, August 19 | vs. Brewers | 12:45 | 1:20 | |
| Saturday, August 20 | vs. Brewers | 12:45 | 1:20 | |
| Sunday, August 21 | vs. Brewers | 12:45 | 1:20 | |
| Monday, August 22 | vs. Cardinals | 6:30 | 7:05 | |
| Tuesday, August 23 | vs. Cardinals (DH Game 1) | 12:45 | 1:20 | |
| Tuesday, August 23 | vs. Cardinals (DH Game 2) | 6:30 | 7:05 | |
| Wednesday, August 24 | vs. Cardinals | 6:30 | 7:05 | |
| Thursday, August 25 | vs. Cardinals | 12:45 | 1:20 | |
| Friday, August 26 | at Brewers | 6:35 | 7:10 | |
| Saturday, August 27 | at Brewers | 5:35 | 6:10 | |
| Sunday, August 28 | at Brewers | 12:35 | 1:10 | |
| Monday, August 29 | at Blue Jays | 5:30 | 6:07 | |
| Tuesday, August 30 | at Blue Jays | 5:30 | 6:07 | |
| Wednesday, August 31 | at Blue Jays | 5:30 | 6:07 | |
| Friday, September 2 | at Cardinals | 6:40 | 7:15 | |
| Saturday, September 3 | at Cardinals | 5:40 | 6:15 | |
| Sunday, September 4 | at Cardinals | 12:40 | 1:15 | |
| Tuesday, September 6 | vs. Reds | 6:05 | 6:40 | |
| Wednesday, September 7 | vs. Reds | 6:05 | 6:40 | |
| Thursday, September 8 | vs. Reds | 12:45 | 1:20 | |
| Friday, September 9 | vs. Giants | 12:45 | 1:20 | |
| Saturday, September 10 | vs. Giants | 12:45 | 1:20 | |
| Sunday, September 11 | vs. Giants | 12:45 | 1:20 | |
| Monday, September 12 | at Mets | 5:35 | 6:10 | |
| Tuesday, September 13 | at Mets | 5:35 | 6:10 | |
| Wednesday, September 14 | at Mets | 5:35 | 6:10 | |
| Friday, September 16 | vs. Rockies | 12:45 | 1:20 | |
| Saturday, September 17 | vs. Rockies | 12:45 | 1:20 | |
| Sunday, September 18 | vs. Rockies | 12:45 | 1:20 | |
| Monday, September 19 | at Marlins | 5:05 | 5:40 | |
| Tuesday, September 20 | at Marlins | 5:05 | 5:40 | |
| Wednesday, September 21 | at Marlins | 5:05 | 5:40 | |
| Thursday, September 22 | at Pirates | 5:00 | 5:35 | |
| Friday, September 23 | at Pirates | 5:00 | 5:35 | |
| Saturday, September 24 | at Pirates | 5:00 | 5:35 | |
| Sunday, September 25 | at Pirates | 11:30 | 12:05 | |
| Tuesday, September 27 | vs. Phillies | 6:05 | 6:40 | |
| Wednesday, September 28 | vs. Phillies | 6:05 | 6:40 | |
| Thursday, September 29 | vs. Phillies | 12:45 | 1:20 | |
| Friday, September 30 | vs. Reds | 12:45 | 1:20 | |
| Saturday, October 1 | vs. Reds | 12:45 | 1:20 | |
| Sunday, October 2 | vs. Reds | 12:45 | 1:20 | |
| Monday, October 3 | at Reds | 5:05 | 5:40 | |
| Tuesday, October 4 | at Reds | 5:05 | 5:40 | |
| Wednesday, October 5 | at Reds | TBD |